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Synthesis of new 5-phenyl [ 1 , 2 , 4 ] triazole derivatives as ligands for the 5-HT 1 A serotonin receptor
| Content Provider | Semantic Scholar |
|---|---|
| Author | Salerno, Loredana Siracusa, Mariangela Guerrera, Francesco Romeo, Giuseppe Pittalà, Valeria Mennini, Tiziana Russo, Filippo |
| Copyright Year | 2006 |
| Abstract | A series of 4-amino-3-[[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]thio]-5-(substituted phenyl)[1,2,4]triazoles (5a-f) and the isomeric 4-amino-2-[2-[4-(2-methoxyphenyl)-1piperazinyl]ethyl]-5-(substitutedphenyl)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (6a-f) and a series of 3-[[2-[4-(2-methoxy or 2-nitrophenyl)1-piperazinyl]ethyl]thio]-5-(substituted phenyl)[1,2,4]triazoles (8a-i) were synthesized with the aim of obtaining new selective 5-HT1A ligands, with reduced affinity for the α1-adrenoceptor subtypes. New compounds were tested in radioligand binding experiments where many of them showed a preferential affinity for the 5HT1A receptor. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://pdf.easechem.com/pdf/21/0c05f250-7295-42d3-8c13-4105fa6ea8b6.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Experiment HTR1A wt Allele Ligands Maxillary right canine abutment Maxillary right central incisor abutment Maxillary right first premolar abutment Processor affinity Subtype (attribute) Triazoles serotonin receptor |
| Content Type | Text |
| Resource Type | Article |
