NDLI: Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

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Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

Content Provider	Semantic Scholar
Author	Suh, Pann Ghill Ryu, Sung Ho Moon, Kyung Ho Rhee, Sue Goo
Copyright Year	1988
Abstract	Antibodies against an inositol phospholipid-specific phospholipase C purified from bovine brain were used to screen rat brain lambda gt11 expression cDNA libraries. Complete sequences of three cDNA inserts yielded a cumulative sequence of 5106 base pairs. The deduced protein had 1289 amino acids with a calculated molecular weight of 148,431. The determination of an open reading frame was aided by the amino acid sequences of 21 tryptic peptides isolated from bovine brain phospholipase C. Only 9 residues of a total of 140 amino acid residues determined for the bovine enzyme were different from those deduced from the rat cDNA. Two regions of phospholipase C (amino acid residues 555-598 and 668-705) exhibited significant amino acid similarities to the products of various tyrosine kinase-related oncogenes (yes, src, fgr, abl, fps, fes, and tck). The homologous domain was located in the region that is not essential for the protein-tyrosine kinase activity but is likely to be involved in an interaction with cellular components that modulate kinase function. Therefore, this unexpected similarity raises the possibility that the 148-kDa phospholipase C and cytoplasmic tyrosine kinases are modulated by common cellular component(s).
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/85/15/5419.full.pdf
PubMed reference number	2840660v1
Volume Number	85
Issue Number	15
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Amino Acid Sequence Amino Acids Base Pairing Bos taurus DNA, Complementary Homologous Gene Inositol Libraries Molecular Weight Oncogene Proteins Oncogenes Open Reading Frames Phosphatidylinositols Phospholipase C Phospholipids Sequence Homology Thioctic Acid protein tyrosine kinase activity
Content Type	Text
Resource Type	Article

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