NDLI: Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials

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Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials

Content Provider	Semantic Scholar
Author	He, Song-jian Liu, Qiang Li, Hua-qiu Tian, Fang Chen, Shi-yu Weng, Jian-xin
Copyright Year	2018
Abstract	Background The prevention of cardiac surgery-associated acute kidney injury (CSA-AKI) by statins remains controversial. Therefore, the present meta-analysis including randomized controlled trials (RCTs) was performed to assess the effect of perioperative statin on CSA-AKI. Methods Two reviewers independently searched for RCTs about perioperative statin for prevention of CSA-AKI. The primary endpoint was CSA-AKI. Relative risk was calculated between statin and placebo for preventing CSA-AKI using the random-effect model or fixed-effect model according to different heterogeneity. Results Eight RCTs met inclusion criteria, including five studies with atorvastatin, two with rosuvastatin, and one with simvastatin. There were 1,603 patients receiving statin treatment and 1,601 with placebo. Perioperative statin therapy did not reduce the incidence of CSA-AKI (relative risk =1.17, 95% CI: 0.98-1.39, p=0.076). Furthermore, perioperative statin increased the risk of CSA-AKI in the subgroup analysis with clear definition of CSA-AKI and those with JADAD score >3. Perioperative rosuvastatin produced slightly significantly higher risk of AKI than atorvastatin therapy (p=0.070). Statin intervention both pre and post surgery slightly increased the risk of CSA-AKI versus preoperative statin therapy alone (p=0.040). Conclusions Perioperative statin therapy might increase the risk of CSA-AKI after cardiac surgery.
Starting Page	475
Ending Page	482
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	29551897v1
Alternate Webpage(s)	https://doi.org/10.2147/TCRM.S160298
DOI	10.2147/tcrm.s160298
Journal	Therapeutics and clinical risk management
Volume Number	14
Language	English
Access Restriction	Open
Subject Keyword	Addison Disease Blighia sapida Cardiac Surgery procedures Cyclosporine Genetic Heterogeneity Kidney Failure, Acute Patients Randomized Controlled Trials as Topic Simvastatin atorvastatin kidney injury rosuvastatin
Content Type	Text
Resource Type	Article

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