NDLI: Anti-melanogenesis and anti-oxidant of Salix pseudo-lasiogyne water extract in α-MSH-induced B16F10 melanoma cells

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Anti-melanogenesis and anti-oxidant of Salix pseudo-lasiogyne water extract in α-MSH-induced B16F10 melanoma cells

Content Provider	Semantic Scholar
Author	Cho, Jung-Hee Shin, Heung-Muk Cho, Hyun-Woo
Copyright Year	2017
Abstract	ABSTRACT The inhibitory effects of Salix pseudo-lasiogyne water extract (SPWE) on melanogenesis were evaluated using intracellular tyrosinase activity and melanin content in B16F10 cells exposed to α-melanocyte-stimulating hormone (α-MSH). Meanwhile, the antioxidative capacity of SPWE was also investigated. SPWE suppressed intracellular tyrosinase activity and decreased the melanin content in B16F10 cells. The results showed that tyrosinase protein expression was suppressed by the SPWE-treated group. SPWE inhibited mRNA and protein expression of microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2. SPWE inhibited the intracellular reactive oxygen species level in B16F10 cells. SPWE not only demonstrated 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH), and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS)-free radical scavenging activity but also possessed chelation capacity and ferric ions (Fe3+) reducing power. We concluded that anti-melanogenesis and antioxidant effect of SPWE may result from the down-regulation MITF and tyrosinase expression and the inhibition ROS generation. Overall, SPWE might be a potential candidate substance for whitening agent about pigmentation.
Starting Page	1003
Ending Page	1016
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1080/09540105.2017.1325840
Volume Number	28
Alternate Webpage(s)	https://www.tandfonline.com/doi/pdf/10.1080/09540105.2017.1325840?needAccess=true
Alternate Webpage(s)	https://doi.org/10.1080/09540105.2017.1325840
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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