Folic acid-conjugated hollow mesoporous silica/CuS nanocomposites as a difunctional nanoplatform for targeted chemo-photothermal therapy of cancer cells.

Content Provider	Semantic Scholar
Author	Liu, Xijian Fu, Fanfan Xu, Kaibing Zou, Rujia Yang, Jianmao Wang, Qian Liu, Qian Xiao, Zhiyin Hu, Junqing
Copyright Year	2014
Abstract	In this work, we have developed a novel difunctional nanoplatform for targeted chemo-photothermal therapy. It is based on hollow mesoporous silica nanospheres as a carrier for anticancer drug-loading CuS nanoparticles attached on a silica nanosphere surface as a photothermal agent, and folic acid (FA) conjugated with a silica nanosphere as a cancer cell target. The nanoplatform has demonstrated a good photothermal effect and excellent doxorubicin (DOX) loading capacity (as high as 49.3 wt%). The photothermal agent and DOX can be targeted to deliver into cancer cells via a receptor mediated endocytosis pathway. Moreover, the release of DOX from the hollow mesoporous silica nanospheres can be triggered by pH and NIR light. Both chemotherapy and photothermal therapy can be simultaneously driven by irradiation with a 980 nm laser. More importantly, the combination of chemotherapy and photothermal therapy shows a better therapy effect than the individual therapies, thus demonstrating a synergistic action.
Starting Page	5358
Ending Page	5367
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1039/C4TB00919C
PubMed reference number	32261756
Journal	Medline
Volume Number	2
Issue Number	33
Alternate Webpage(s)	http://www.rsc.org/suppdata/tb/c4/c4tb00919c/c4tb00919c1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C4TB00919C
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article