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Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mousavi, Faezeh Eidi, Akram Khalili, Mohsen Roghani, Mehrdad |
| Copyright Year | 2018 |
| Abstract | Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assigned to 4 groups: control, control treated with metformin (200 mg/kg), diabetic, and diabetic treated with metformin (200 mg/kg). Diabetes was induced by streptozotocin (STZ) at a dose of 60 mg/kg. Metformin was administered i.p. at a dose of 200 mg/kg one week after STZ injection for 7 weeks. Blood sample was taken from retro-orbital plexus before STZ injection and 4 and 8 weeks after STZ injection to measure blood glucose level. Passive avoidance and Y maze tests were performed to evaluate learning and memory dysfunctions. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jbcp.shahed.ac.ir/article_621_8c402d45523670d31b92323d1d9f3007.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Glucose Diabetes Mellitus Memory Disorders Metformin Molecular orbital PersonNameUse - assigned Plexus Randomness Streptozocin mg/kg |
| Content Type | Text |
| Resource Type | Article |
