Étude moléculaire du recrutement des gènes de résistance aux antibiotiques

Content Provider	Semantic Scholar
Author	Tremblay, Simon
Copyright Year	2007
Abstract	Insertion séquences are DNA molecular parasites encoding exclusively their transposition function, and are mainly found within the génomes and plasmids of prokaryotic organisms. The massive genomic sequencing we hâve witnessed in the last décade has allowed us to detect in clinical bacterial isolâtes many antibiotic résistance gènes associated with insertion séquences in the form of composite transposons. It has been suggested that insertion séquences may act as a primary modulator of bacterial évolution, and that they possess a recruitment capacity allowing them to sélect, reorganize and spread gènes encoding adaptation functions for their hosts. We hâve partially characterized the recruitment potential of two insertion séquences well known for their association with antibiotic résistance gènes, IS10 from Salmonella typhimurium and 1S26 from Proteus vulgaris, by observing the steps involved in the recruitment process of a chromosomal gène and their epidemiological distribution by consulting various databanks.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/19008/1/24374.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article