NDLI: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety† †Electronic supplementary information (ESI) available. CCDC 154150–154153. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ob02289a

Content Provider	Semantic Scholar
Author	Sansook, Supojjanee Ocasio, Cory A. Day, Iain J. Tizzard, Graham J. Coles, Simon J. Fedorov, Oleg Bennett, James E. M. Elkins, Jonathan M. Spencer, James
Copyright Year	2017
Abstract	A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
Starting Page	8655
Ending Page	8660
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	28984325v1
Alternate Webpage(s)	https://doi.org/10.1039/c7ob02289a
DOI	10.1039/c7ob02289a
Journal	Organic & biomolecular chemistry
Volume Number	15
Language	English
Access Restriction	Open
Subject Keyword	Aldehydes Cultured Cell Line Digit structure Digital Object Identifier Electronic Supplementary Materials
Content Type	Text
Resource Type	Article

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