Probing the Internal Morphology of Injectable Poly(oligoethylene glycol methacrylate) Hydrogels by Light and Small-Angle Neutron Scattering

Content Provider	Semantic Scholar
Author	Smeets, Niels M. B. Bakaic, Emilia Yavitt, Francis M. Yang, Fei-Chi Rheinstädter, Maikel C. Hoare, Todd
Copyright Year	2014
Abstract	While injectable, in situ gelling hydrogels have attracted increasing attention in the biomedical literature due to their minimally invasive administration potential, little is known about the internal morphology of these hydrogels and thus how to engineer precursor polymer compositions to achieve desired hydrogel properties. In this paper, the internal morphology of injectable in situ gelling hydrogels based on hydrazide and aldehyde-functionalized poly(oligoethylene glycol methacrylate) precursors with varying lower critical solution temperatures (LCSTs) is investigated using a combination of spectrophotometry, small-angle neutron scattering, and light scattering. If two precursor polymers with similar LCSTs are used to prepare the hydrogel, relatively homogeneous hydrogels are produced (analogous to conventional step-growth polymerized hydrogels); this result is observed provided that gelation is sufficiently slow for diffusional mixing to compensate for any incomplete mechanical mixing in the double-b...
Starting Page	6017
Ending Page	6027
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1021/ma5011827
Volume Number	47
Alternate Webpage(s)	http://www.rheinstaedter.de/maikel/publications/PDF/Smeets_Probing%20the%20Internal%20Morphology%20of%20Injectable%20Poly(oligoethylene%20glycol%20methacrylate)%20Hydrogels%20by%20Light%20and%20Small-Angle%20Neutron%20Scattering.pdf
Alternate Webpage(s)	https://doi.org/10.1021/ma5011827
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article