NDLI: eIF2B, a mediator of general and gene-specific translational control.

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eIF2B, a mediator of general and gene-specific translational control.

Content Provider	Semantic Scholar
Author	Pavitt, Graham D.
Copyright Year	2005
Abstract	eIF2B (eukaryotic initiation factor 2B) is a multisubunit protein that is required for protein synthesis initiation and its regulation in all eukaryotic cells. Mutations in eIF2B have also recently been found to cause a fatal human disease called CACH (childhood ataxia with central nervous system hypomyelination) or VWM (vanishing white matter disease). This review provides a general background to translation initiation and mechanisms known to control eIF2B function, before describing molecular genetic and biochemical analysis of eIF2B structure and function, integrating work from studies of the yeast and mammalian eIF2B proteins.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemsoctrans.org/content/ppbiost/33/6/1487.full.pdf
PubMed reference number	16246152v1
Volume Number	33
Part	6
Journal	Biochemical Society transactions
Language	English
Access Restriction	Open
Subject Keyword	ATF4 gene Amino Alcohols Biological Science Disciplines CNS disorder Childhood Ataxia with Central Nervous System Hypomyelinization Contrecoup Injury Eukaryotic Initiation Factor-2B, beta Subunit F Factor Genetic Translation Process Leukodystrophy Leukoencephalopathies Mammals Mediator brand of benfluorex hydrochloride Nervous system structure Peptide Initiation Factors Protein Biosynthesis Transcription Initiation Translation Initiation White matter funding grant
Content Type	Text
Resource Type	Article

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