NDLI: Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons

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Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons

Content Provider	Semantic Scholar
Author	Centonze, Diego Rossi, Silvia Liliana Prosperetti, Chiara Gasperi, Valeria Maccarrone, Mauro
Copyright Year	2007
Abstract	Synaptic transmission in the striatum is regulated by metabotropic glutamate (mGlu) receptors through pre- and postsynaptic mechanisms. We investigated the involvement of mGlu 1 and 5 receptors in the control of both excitatory and inhibitory transmission in the striatum. The mGlu 1 and 5 receptor agonist 3,5-DHPG failed to affect glutamate transmission, while it caused a biphasic effect on GABA transmission, characterized by early increase and late decrease in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from striatal principal neurons. Both mGlu 1 and 5 receptors were involved in the early response to 3,5-DHPG, through membrane depolarization of striatal GABAergic interneurons and action potential generation. The 3,5-DHPG-mediated late depression of inhibitory inputs to striatal principal neurons was conversely secondary to mGlu 5 receptor activation and subsequent endocannabinoid release. In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity.
Starting Page	302
Ending Page	310
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1016/j.mcn.2007.03.005
PubMed reference number	17434747
Journal	Medline
Volume Number	35
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S1044743107000620
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S1044743107000620?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.mcn.2007.03.005
Journal	Molecular and Cellular Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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