NDLI: Es útil el estudio de la inmunogenicidad en los tratamientos biológicos en psoriasis

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Es útil el estudio de la inmunogenicidad en los tratamientos biológicos en psoriasis

Content Provider	Semantic Scholar
Author	Rivera, Rafael Vanaclocha, Francisco Herranz, Pedro
Copyright Year	2015
Abstract	espanolEl uso de farmacos biologicos ha revolucionado el tratamiento de muchas enfermedades inflamatorias, entre ellas la psoriasis. Pero no siempre los pacientes responden adecuadamente a estos tratamientos. Una de las causas de perdida de eficacia es la inmunogenicidad por la aparicion de anticuerpos frente a estos farmacos. Tambien es motivo de la aparicion de efectos adversos. Hasta ahora, en la practica clinica no disponiamos de herramientas adecuadas para la determinacion de estos anticuerpos antifarmacos; hoy ya disponemos de ellas. Hay pocos estudios en enfermos con psoriasis para conocer la relevancia de estas determinaciones. En este articulo nos proponemos revisar la importancia de la inmunogenicidad en los tratamientos biologicos y valorar su aplicacion en la practica clinica. EnglishThe use of biological therapy has revolutionated the treatment of many inflammatory diseases; one of them, psoriasis. But not always patients respond adequately to these treatments. One of the reasons of lost of efficacy is immunogenicity, as a result of the appearance of antibodies against these agents. Furthermore it is a reason for the adverse events to happen. Until now in clinical practice we did not have the adequated tools to detect these antidrug-antibodies, nowadays we have them. There are few studies in psoriatic patients to know the relevance of these detections. In this paper we want to review the significance of the immunogenicity in the biological treatments and their value in clinical practice.
Starting Page	10
Ending Page	17
Page Count	8
File Format	PDF HTM / HTML
Volume Number	43
Alternate Webpage(s)	http://www.medigraphic.com/pdfs/cutanea/mc-2015/mc151c.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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