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Pretargeted radioimmunotherapy for B-cell lymphomas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Green, Damian J. Pagel, John M. Pantelias, Anastasia Hedin, Nathan Lin, Yukang Wilbur, Daniel Scott Gopal, Ajay K. Hamlin, Donald K. |
| Copyright Year | 2007 |
| Abstract | Relapsed or treatment refractory B-cell lymphomas are currently incurable with conventional chemotherapy and radiation treatments. High-dose chemoradiotherapy and stem cell transplantation can cure some patients with relapsed or refractory lymphoma, but the majority of such patients die of progressive disease. We have investigated the potential utility of pretargeted radioimmunotherapy using monoclonal antibody-streptavidin, immunoconjugates, and fusion proteins in combination with N-acetylgalactosamine dendrimeric clearing agent and radiometal-labeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid biotin for treatment of lymphomas using mouse and primate models. We have targeted a variety of cell surface antigens, including CD20, CD22, CD45, and HLA-DR, using conventional and pretargeted radioimmunotherapy. These studies showed the marked superiority of pretargeted radioimmunotherapy for each of the antigenic targets in terms of superior biodistributions, more complete tumor regressions, and longer survival. We are optimistic that this novel approach will provide a meaningful prolongation of survival for patients with relapsed or refractory lymphomas. |
| Starting Page | 5598s |
| Ending Page | 5603s |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1158/1078-0432.CCR-07-1223 |
| PubMed reference number | 17875795 |
| Journal | Medline |
| Volume Number | 13 |
| Issue Number | 18 |
| Part | 2 |
| Alternate Webpage(s) | http://clincancerres.aacrjournals.org/content/clincanres/13/18/5598s.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1158/1078-0432.CCR-07-1223 |
| Journal | Clinical cancer research : an official journal of the American Association for Cancer Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
