NDLI: A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder

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A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder

Content Provider	Semantic Scholar
Author	Guastella, Adam J. Richardson, Rick Lovibond, Peter F. Rapee, Ronald M. Dadds, Mark R.
Copyright Year	2008
Abstract	BACKGROUND Pilot research has suggested that D-cycloserine (DCS) enhances treatment outcomes for anxiety disorders when employed as an adjunct to exposure therapy (ET). The aim of this study was to determine whether 50 mg of DCS enhances ET for social anxiety disorder (SAD) according to a comprehensive set of symptom and life impairment measures. METHODS In a randomized double-blind placebo-controlled trial, we administered 50 mg of DCS or placebo in combination with ET to 56 participants who met primary diagnosis for SAD. RESULTS Participants administered DCS reported greater improvement on measures of symptom severity, dysfunctional cognitions, and life-impairment from SAD in comparison with placebo-treated participants. Effect sizes were mostly in the medium range. Results also indicated that the amount of adaptive learning about one's ability to give speeches in front of an audience interacted with DCS to enhance treatment outcome. CONCLUSIONS This study shows that the administration of DCS before ET enhances treatment outcomes for SAD. Results also provide the first preliminary evidence to suggest that DCS moderates the relationship between a reduction in negative appraisals about one's speech performance and improvement in overall SAD symptoms.
Starting Page	544
Ending Page	549
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/j.biopsych.2007.11.011
PubMed reference number	18179785
Journal	Medline
Volume Number	63
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006322307011055
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006322307011055?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.biopsych.2007.11.011
Journal	Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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