NDLI: Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1

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Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1–40) protein

Content Provider	Semantic Scholar
Author	Yamada, Kiyofumi Nitta, Atsumi Saito, Tsuyoshi Hu, Jianguo Nabeshima, Toshitaka
Copyright Year	1995
Abstract	We have previously shown that the continuous intracerebroventricular infusion of beta-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of beta-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The beta-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of beta-amyloid(1-40) in the brain may affect CNTF production in vivo.
Starting Page	155
Ending Page	158
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(95)12161-7
PubMed reference number	8848241
Journal	Medline
Volume Number	201
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394095121617
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394095121617?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2895%2912161-7
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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