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Relative contributions of 5-hydroxytryptamine (5-HT) receptor subtypes in 5-HT-induced vasoconstriction of the distended human saphenous vein as a coronary artery bypass graft.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nakamura, Eisaku Tanaka, Naoko Kuwabara, Masachika Yamashita, Atsushi Matsuo, Yasuko Kanai, Tasuku Onitsuka, Toshio Asada, Yujiro Hisa, Hiroaki Yamamoto, Ryuichi |
| Copyright Year | 2011 |
| Abstract | It is established that the segment of saphenous vein (SV) that is widely used as a conduit vessel in coronary artery bypass graft (CABG) surgery is distended with high pressure to check for leaks and to increase the patency before implantation into coronary arterial circulation. The aim of the present study was to elucidate the relative contributions of 5-hydroxytryptamine (5-HT) receptor subtypes responsible for 5-HT-induced vasoconstriction of the distended human SV. Whereas about half of the 5-HT-induced vasoconstriction still remained in the presence of supramaximum concentration of sarpogrelate or of SB224289 (5-HT(2A) and 5-HT(1B) receptor antagonists, respectively), simultaneous treatment with sarpogrelate and SB224289 almost completely inhibited the 5-HT-induced vasoconstriction. Immunopositive staining for 5-HT(2A) and 5-HT(1B) receptors was detected in smooth muscle cells of the distended human SV and there was no significant difference between the immunopositive areas of 5-HT(2A) and 5-HT(1B) receptors. These results demonstrate that 5-HT(2A) and 5-HT(1B) receptors similarly contribute to 5-HT-induced vasoconstriction in human distended SV. Thus, when the SV is used as a CABG conduit, a combination of 5-HT(2A) and 5-HT(1B) receptor antagonists would appear to be most useful to prevent 5-HT-induced spasm. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/bpb/34/1/34_1_82/_pdf/-char/en |
| PubMed reference number | 21212522v1 |
| Volume Number | 34 |
| Issue Number | 1 |
| Journal | Biological & pharmaceutical bulletin |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Vessel Tissue Coronary Artery Bypass Surgery Myocytes, Smooth Muscle Receptor, Serotonin, 5-HT1B SB-224289 Saphenous Vein Serotonin Smooth muscle (tissue) Spasm Staining method Subtype (attribute) Vascular constriction (function) sarpogrelate |
| Content Type | Text |
| Resource Type | Article |
