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1,N6-Etheno-7-deaza-2,8-diazaadenosine: syntheses, properties and conversion to 7-deaza-2,8-diazaadenosine.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lin, Wenqing Ming, Xin Seela, Frank |
| Copyright Year | 2005 |
| Abstract | 1,N6-Etheno-7-deaza-2,8-diazaadenosine (4) was synthesized from 8-aza-7-deazaadenosine (6) in 64% overall yield. The starting material 6 was obtained by the direct glycosylation of 8-aza-7-deazaadenine (7) with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d-ribofuranose (8) (NO2 CH3, BF3 x Et2O; 77% yield). Compound 4 was transformed into 7-deaza-2,8-diazaadenosine (5). The fluorescence of compound 4 shows an emission maximum at 531 nm (phosphate buffer; pH 7.0), which is bathochromically shifted compared to 1,N(6)-etheno-2-azaadenosine (3a) (495 nm). A conformational analysis was performed in the solid state and in solution. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.seela.net/pdf/publications/436.pdf |
| PubMed reference number | 15858655v1 |
| Volume Number | 3 |
| Issue Number | 9 |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 4-aminopyrazolopyrimidine-2'-deoxyribofuranoside 7-deaza-2,8-diazaadenosine 8-aza-7-deazaadenine Chorionic Gonadotropin, beta Subunit, Human Fluorescence Maxillary right first molar abutment PHOSPHATE BUFFERS inorganic phosphate |
| Content Type | Text |
| Resource Type | Article |