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Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, Jihoon Oh, Young Taik Lee, Kyung Soo Yun, Jeong Min Park, Byung Tae Oh, Kyung Taek |
| Copyright Year | 2011 |
| Abstract | AbstractpH sensitive polymer systems can be utilized as smart nanocarriers to deliver hydrophobic drugs specifically to solid tumors or to acidosis-affected rheumatic joints. In this study, a poly(L-aspartic acid-graftimidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG) block copolymer was synthesized as a pH sensitive nanocarrier targeting acidic pH environments. The polypeptide P(Asp), which was used as a backbone for the hydrophobic block, was synthesized by ring opening polymerization with N-carboxylanhydride (NCA) of β-benzyl-aspartic acid. PEG was included as the hydrophilic block and the polymer was functionalized with imidazole groups to confer pH sensitivity. The prepared P(Asp-g-Im)-PEG is zwitterionic with a pI 6.5; 60% of the available carboxyl groups of P(Asp)-PEG were substituted by imidazole groups. Furthermore, the potentiometric titration curve of P(Asp-g-Im)-PEG demonstrated a broad buffer zone. The micelles prepared from P(Asp-g-Im)-PEG showed pH dependent critical micelle concentrations (CMC), particle sizes, zeta potentials, and morphologies. |
| Starting Page | 453 |
| Ending Page | 460 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s13233-011-0502-z |
| Volume Number | 19 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s13233-011-0502-z |
| Alternate Webpage(s) | https://doi.org/10.1007/s13233-011-0502-z |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
