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Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
| Content Provider | Semantic Scholar |
|---|---|
| Author | Spyridopoulou, Katerina Tiptiri-Kourpeti, Angeliki Lampri, Evangeli S. Fitsiou, Eleni Vasileiadis, Stavros Vamvakias, Manolis Bardouki, Haido Goussia, Anna Malamou-Mitsi, Vasiliki Panayiotidis, Mihalis I. Galanis, Alex Pappa, Aglaia Chlichlia, Katerina |
| Copyright Year | 2017 |
| Abstract | Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a). When administered orally, mastic oil inhibited the growth of colon carcinoma tumors in mice. A reduced expression of Ki-67 and survivin in tumor tissues accompanied the observed effects. Notably, only mastic oil -which is comprised of 67.7% α-pinene and 18.8% myrcene- induced a statistically significant anti-tumor effect in mice but not α-pinene, myrcene or a combination thereof. Thus, mastic oil, as a combination of terpenes, exerts growth inhibitory effects against colon carcinoma, suggesting a nutraceutical potential in the fight against colon cancer. To our knowledge, this is the first report showing that orally administered mastic oil induces tumor-suppressing effects against experimental colon cancer. |
| File Format | PDF HTM / HTML |
| DOI | 10.1038/s41598-017-03971-8 |
| PubMed reference number | 28630399 |
| Journal | Medline |
| Volume Number | 7 |
| Alternate Webpage(s) | http://nrl.northumbria.ac.uk/31160/2/Scientific%20Reports%20(Final%20Draft).pdf |
| Alternate Webpage(s) | http://nrl.northumbria.ac.uk/31160/1/Scientific%20Reports%20(Published%20Manuscript).pdf |
| Alternate Webpage(s) | https://doi.org/10.1038/s41598-017-03971-8 |
| Journal | Scientific Reports |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
