Estudo da influência da inflamação na patogênese do melasma / análise da qualidade de vida

Content Provider	Semantic Scholar
Author	Ikino, Juliana Kida
Copyright Year	2013
Abstract	Introduction: Melasma is a skin disease characterized by the presence of dark spots on the face and sun-exposed areas. There are several factors involved in its pathogenesis, but the mechanisms that lead to their appearance are not yet fully understood. Objectives: To study the inflammatory response through the evaluation of cellularity, edema and apoptosis of keratinocytes in the lesions of melasma, assess the presence or absence of telangiectasias, elastosis and epidermal pigment in melasma lesions, assess the involvement of nitric oxide in melasma lesions, assess the impact on quality of life through an already validated to Portuguese language questionnaire (MelasQol). Methods: This is an observational cross-sectional study with analytical component. The sample was defined as convenience. We selected 51 patients with clinical diagnosis from Hospital Universitario Professor Polydoro Ernani de Sao Thiago da Universidade Federal de Santa Catarina (HU-UFSC) between January 2011 and December 2011. This study involved the collection of clinical data and the questionnaire MelasQol in all selected patients and biopsies from 31 patients with melasma. In the protocol four biopsies were performed with 2-mm punch, two samples from melasma area and two from adjacent normal skin with minimum distance of 1cm between them. The first fragment area of each was submitted for histological analysis and the second for dosage of nitric oxide. The nitric oxide formation was quantitated by their metabolic nitrite (NO2-) and nitrate (NO3-) using the Griess reaction. Results: The mean age was 38.43 ± 6.75 years, all patients were female, and the most common skin types were III (49.02%) and IV (33.33%). The mean age at disease onset and disease duration were 29.18 ± 7.05, 09.25 ± 6.18 years. Histological evaluation showed statistically significance on the presence of solar elastosis (P = 0.001) and increased melanin pigmentation of the epidermis (P <0.001) when compared the samples of melasma lesion and normal skin. The dosage of nitrite / nitrate metabolites in lesional and perilesional skin showed no statistical difference between groups. The MelasQol analysis showed that 94.11% of patients feel uncomfortable with the appearance of their skin, 64.71% feel frustration or embarrassment the condition of their skin, 52.94% felt depressed and 78.43% have the feeling of not being attractive. However, for 68.63% of patients, melasma does not affect relations with other people, 86.27% of patients feel no difficulty in showing affection, 66.67% do not feel less productive and 74.51% did not affect their sense of freedom. Conclusion: Our study demonstrated that in melasma there is an increase in the solar elastosis and it is associated with an increased pigmentation in the epidermis. Melasma is also implicated in the impact on quality of life, and our study showed that the domain of quality of life that was most affected by melasma was emotional wellbeing, and that there was little impact in the domain of social relations.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://repositorio.ufsc.br/bitstream/handle/123456789/101064/317535.pdf?sequence=1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article