NDLI: Ginkgolide K protects SH-SY5Y cells against oxygen-glucose deprivation-induced injury by inhibiting the p38 and JNK signaling pathways

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Ginkgolide K protects SH-SY5Y cells against oxygen-glucose deprivation-induced injury by inhibiting the p38 and JNK signaling pathways

Content Provider	Semantic Scholar
Author	Li, Xueke Li, Liang Xu, Zhiliang Zhou, Jun Xiao, Wei
Copyright Year	2018
Abstract	The purpose of the present study was to explore the protective effect and functional mechanism of ginkgolide K (GK: C20H22O9) on cerebral ischemia. SH‑SY5Y cells were exposed to oxygen‑glucose deprivation (OGD) to simulate an ischemic model in vitro. Cell viability, reactive oxygen species (ROS), nuclear staining with Hoechst 33258 and mitochondrial membrane potential were detected following 4 h of exposure to OGD. Subsequently, the expression levels of the apoptosis‑related proteins, caspase‑9, caspase‑3, Bcl‑2, Bax, p53 and c‑Jun, as well as the mitogen‑activated protein kinases (MAPKs) signaling molecules were detected by western blot analysis. GK significantly elevated the cell viability and decreased the generation of ROS and the number of apoptotic cells in a dose‑dependent manner. Furthermore, GK markedly decreased the protein expression levels of p‑p38, p‑JNK, p‑p53, p‑c‑Jun and the expression levels of Bcl‑2, Bax, cleaved caspase‑9 and caspase‑3. In conclusion, GK demonstrated a neuroprotective effect on the simulated cerebral ischemia in vitro, and this effect was mediated through the inhibition of the mitochondria‑mediated apoptosis pathway triggered by ROS‑evoked p38 and JNK activation.
Starting Page	3185
Ending Page	3192
Page Count	8
File Format	PDF HTM / HTML
DOI	10.3892/mmr.2018.9305
PubMed reference number	30066915
Journal	Medline
Volume Number	18
Alternate Webpage(s)	https://www.spandidos-publications.com/mmr/18/3/3185/download
Alternate Webpage(s)	https://www.spandidos-publications.com/10.3892/mmr.2018.9305/download
Alternate Webpage(s)	https://doi.org/10.3892/mmr.2018.9305
Journal	Molecular medicine reports
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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