NDLI: Avian Influenza: A New Pandemic Threat?

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Avian Influenza: A New Pandemic Threat?

Content Provider	Semantic Scholar
Author	Trampuz, Andrej Prabhu, Raghunatha Smith, Thomas F. A. Baddour, Larry M.
Copyright Year	2004
Abstract	In December 2003, the largest outbreak of highly pathogenic avian influenza H5N1 occurred among poultry in 8 Asian countries. A limited number of human H5N1 infections have been reported from Vietnam and Thailand, with a mortality rate approaching 70%. Deaths have occurred in otherwise healthy young individuals, which is reminiscent of the 1918 Spanish influenza pandemic. The main presenting features were fever, pneumonitis, lymphopenia, and diarrhea. Notably, sore throat, conjunctivitis, and coryza were absent. The H5N1 strains are resistant to amantadine and rimantadine but are susceptible to neuraminidase inhibitors, which can be used for treatment and prophylaxis. The widespread epidemic of avian influenza in domestic birds increases the likelihood for mutational events and genetic reassortment. The threat of a future pandemic from avian influenza is real. Adequate surveillance, development of vaccines, outbreak preparedness, and pandemic influenza planning are important. This article summarizes the current knowledge on avian influenza, including the virology, epidemiology, diagnosis, and management of this emerging disease.
Starting Page	523
Ending Page	530
Page Count	8
File Format	PDF HTM / HTML
DOI	10.4065/79.4.523
PubMed reference number	15065617
Journal	Medline
Volume Number	79
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0025619611627699
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0025619611627699
Alternate Webpage(s)	https://doi.org/10.4065/79.4.523
Journal	Mayo Clinic Proceedings
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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