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Next generation sequencing and molecular imaging identify EGFR mutation and amplification in a glioblastoma multiforme patient treated with an EGFR inhibitor: a case report
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhou, Ke Yao, Hui Zhang, Xuewen Liu, Jiangang Qi, Zhenyu Xie, Xueshun Xu, Xiaoting Zhou, Youxin Yu, Zhengquan Wang, Zhong Che, Yanjun Huang, Yulun |
| Copyright Year | 2017 |
| Abstract | Epidermal growth factor receptor (EGFR) mutations and amplifications are frequently reported in glioblastoma multiforme (GBM) patients. In this case report, we utilize next-generation sequencing (NGS) and EGFR molecular imaging to investigate intratumoral heterogeneity in a male patient presenting with GBM. Further, we describe the patient's clinical course as well as outcomes of targeted EGFR therapy with erlotinib, an EGFR tyrosine kinase inhibitor (TKI). NGS demonstrated the presence of an EGFR mutation and amplification in our patient. Molecular imaging revealed a heterogeneous expression pattern of EGFR in the frontal and temporal lobes. This patient briefly responded to erlotinib therapy. However, the patient relapsed and died from progressive neurological deterioration. Partial response and acquired secondary resistance may be attributed to intratumoral heterogeneity. Combination of NGS and EGFR molecular imaging may be helpful in understanding intratumoral molecular heterogeneity and may aid in developing individualized GBM treatments, thereby improving outcomes. |
| Starting Page | 50305 |
| Ending Page | 50313 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=18148&path%5B%5D=58192 |
| PubMed reference number | 28611289v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.18148 |
| DOI | 10.18632/oncotarget.18148 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biopolymer Sequencing Cessation of life Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gene Amplification Technique Genetic Heterogeneity Glioblastoma Multiforme Massively-Parallel Sequencing Mutation Patients Protein Tyrosine Kinase Protein-tyrosine kinase inhibitor Temporal Lobe erlotinib negative regulation of phosphorylation of RNA polymerase II C-terminal domain nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
