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Dynamic modeling of cellular response to DNA damage based on p53 stress response networks
| Content Provider | Semantic Scholar |
|---|---|
| Author | Qi, Jinpeng Ding, Yongsheng Shao, Shihuang |
| Copyright Year | 2009 |
| Abstract | Abstract Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation (IR), a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks (DSBs) generation and their repair, switch-like ataxia telangiectasia mutated (ATM) activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes. |
| Starting Page | 1349 |
| Ending Page | 1356 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.pnsc.2009.03.008 |
| PubMed reference number | 32288404 |
| Journal | Medline |
| Volume Number | 19 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1002007109001919 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1002007109001919 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.pnsc.2009.03.008 |
| Journal | Progress in Natural Science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
