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An exploratory study of adolescent response to fluoxetine using psychological and biological predictors
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zohar, Ada H. Eilat, Tamar Amitai, Maya Taler, Michal Bari, Romi Chen, Alon Apter, Alan Stanley Weizman, Avraham Fennig, Silvana |
| Copyright Year | 2018 |
| Abstract | Background Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. Methods Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. Results There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. Conclusions In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility. |
| Starting Page | 727 |
| Ending Page | 732 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://peerj.com/articles/4240.pdf |
| PubMed reference number | 29340244v1 |
| Alternate Webpage(s) | https://doi.org/10.7717/peerj.4240 |
| DOI | 10.7717/peerj.4240 |
| Journal | PeerJ |
| Volume Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antisocial Personality Disorder Anxiety Disorders Biological Markers Classification Data Table Depressive disorder Digital Object Identifier Fluoxetine Greater Histrionic Personality Disorder Interleukin-6 Mental disorders Morbidity - disease rate Outpatients Patients Personality Assessment Providing (action) Psychotropic Drugs Reagents Score Serotonin Type D Personality drug response interest |
| Content Type | Text |
| Resource Type | Article |
