Smoking and osteoarthritis: is there an association? The Clearwater Osteoarthritis Study.

Content Provider	Semantic Scholar
Author	Wilder, Frances Vaughn
Copyright Year	2003
Abstract	OBJECTIVE To evaluate the association between cigarette smoking and the subsequent development of osteoarthritis (OA) at four separate sites: knee, hand, foot and cervical spine. METHODS This cohort study examined 2505 men and women aged 40 years and older participating in the longitudinal Clearwater Osteoarthritis Study (1988-current). Biennial physical exams, including serial radiographs, as well as historical information, were collected. The Lawrence and Kellgren ordinal scale was used to determine radiological evidence of the study outcome, OA. Self-reported history of smoking behavior was used to determine the study exposure. Smoking was classified using four approaches: (1) ever/never, (2) former/never, (3) current/never, and (4) dose. RESULTS Among the individuals at study entry, radiologically confirmed incident OA was detected during the follow-up period at four sites: knee (32%), hand (49%), foot (28%), and cervical spine (52%). Approximately 11% were self-reported current smokers. Unadjusted analyses indicated that individuals classified as current smokers demonstrated significant levels of protection from OA at all four sites investigated. However, adjusted point estimates ranging from 0.60-1.48 were suggestive of no association between smoking and the development of OA at any of the four sites investigated. CONCLUSION Based upon the findings of this prospective study, smoking does not appear to convey a clinically significant level of protection against the development of radiologically-confirmed OA. While these findings corroborate previous studies indicating no association between smoking and OA, anecdotal evidence warrants investigation into the role that cigarette smoking may play in the symptomatology of OA.
Starting Page	29
Ending Page	35
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://preventarthritis.org/wp-content/uploads/2012/10/WilderSmoking2003.pdf
PubMed reference number	12505484v1
Volume Number	11
Issue Number	1
Journal	Osteoarthritis and cartilage
Language	English
Access Restriction	Open
Subject Keyword	Cervical spine Cigarette smoke (substance) Cigarette smoking behavior Classification Degenerative polyarthritis Estimated Forty Nine Neck Osteoarthritis of hip REM Sleep Behavior Disorder
Content Type	Text
Resource Type	Article