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Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rajashree, R. Kholkute, Sanjiva D. Goudar, Shivaprasad S. |
| Copyright Year | 2011 |
| Abstract | BACKGROUND Diabetic encephalopathy is a recently recognised complication of early-onset type 1 diabetes in children. The abnormalities underlying diabetic encephalopathy are complex and poorly understood, and the impact of disease duration on behavioural and cognitive parameters also remains unclear. Hence, the present study was conducted to determine the effects of different durations of hyperglycaemia on behavioural and cognitive parameters in young streptozotocin-induced diabetic rats. METHODS Diabetes was induced in young, weaned, age-matched rat pups by streptozotocin injection (50 mg/kg body weight, intraperitoneally). Diabetic status was confirmed on post-natal day 30. The rats were tested in the elevated plus maze 10 and 2o days after diabetes induction. RESULTS Diabetic rats had significantly impaired behavioural and cognitive functions compared with age-matched controls. Increased anxiety levels and cognitive deficits were observed in rats that had been diabetic for 20 days compared with their 10-day counterparts. CONCLUSION It is essential to diagnose and treat early-onset type 1 diabetes in young children to prevent irreversible cognitive dysfunction. |
| Starting Page | 26 |
| Ending Page | 31 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 22589670 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.bioline.org.br/pdf?mj11050 |
| Journal | The Malaysian journal of medical sciences : MJMS |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
