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For Searching for Highly Divergent Tandem Repeats in Dna Sequences , Statistical Tests , and Biological Application in Drosophila Melanogaster Genome
| Content Provider | Semantic Scholar |
|---|---|
| Author | J. Makeev V. |
| Copyright Year | 2008 |
| Abstract | Motivation: Tandem repeats occur in regions of various functions in genomes. Highly divergent tandem repeats are difficult to separate from random background without focused statistical tests. Thus, the majority of tools designed to identify tandem repeats, which do not includes statistical evaluations of the results are not suitable for identification of divergent tandem repeats. Results: We developed an effective algorithm for searching for highly divergent tandem repeats with evaluation of their statistical significance and implemented it in the SWAN software. In addition to identification of tandem repeats in a sequence, SWAN can be used to compute statistical significance of repeated structures identified by other popular tools designed for repeat finding. A number of biological examples of tandem repeats identified with SWAN are presented. Availability: tool is available upon request from the authors. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bionet.nsc.ru/meeting/bgrs_proceedings/papers/2004/BGRS_2004_V1_006.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |