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Mechanical characterization of collagen fibers and scaffolds for tissue engineering.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gentleman, Eileen Lay, Andrea N. Dickerson, Darryl |
| Copyright Year | 2003 |
| Abstract | Engineered tissues must utilize scaffolding biomaterials that support desired cellular functions and possess or can develop appropriate mechanical characteristics. This study assessed properties of collagen as a scaffolding biomaterial for ligament replacements. Mechanical properties of extruded bovine achilles tendon collagen fibers were significantly affected by fiber diameter, with smaller fibers displaying higher tangent moduli and peak stresses. Mechanical properties of 125 micrometer-diameter extruded fibers (tangent modulus of 359.6+/-28.4MPa; peak stress of 36.0+/-5.4MPa) were similar to properties reported for human ligaments. Scaffolds of extruded fibers did not exhibit viscoelastic creep properties similar to natural ligaments. Collagen fibers from rat tail tendon (a well-studied comparison material) displayed characteristic strain-softening behavior, and scaffolds of rat tail fibers demonstrated a non-intuitive relationship between tangent modulus and specimen length. Composite scaffolds (extruded collagen fibers cast within a gel of Type I rat tail tendon collagen) were maintained with and without fibroblasts under standard culture conditions for 25 days; cell-incorporated scaffolds displayed significantly higher tangent moduli and peak stresses than those without cells. Because tissue-engineered products must possess appropriate mechanical as well as biological/chemical properties, data from this study should help enable the development of improved tissue analogues. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://orzo.union.edu/~curreyj/BNG-338_files/Gentleman%20et%20al_Biomaterials_2003.pdf |
| Alternate Webpage(s) | http://antipasto.union.edu/~curreyj/BNG-331_files/Gentleman%20et%20al_Biomaterials_2003.pdf |
| Alternate Webpage(s) | http://orzo.union.edu/~curreyj/BNG-331_files/LBL%20Example.pdf |
| Alternate Webpage(s) | http://orzo.union.edu/~curreyj/BNG-331_files/Gentleman%20et%20al_Biomaterials_2003.pdf |
| Alternate Webpage(s) | http://orzo.union.edu/~curreyj/BNG-338_files/LBL%20Example.pdf |
| PubMed reference number | 12818553v1 |
| Volume Number | 24 |
| Issue Number | 21 |
| Journal | Biomaterials |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body tissue CDISC SEND Biospecimens Terminology Collagen fiber Diameter (qualifier value) Ligaments Micron Small Structure of achilles tendon Surgical Replantation Tendon structure Tissue Engineering Tissue fiber |
| Content Type | Text |
| Resource Type | Article |
