NDLI: Identificación de factores de riesgo genéticos asociados a la enfermedad vascular cerebral de tipo isquémico en jóvenes mexicanos

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Identificación de factores de riesgo genéticos asociados a la enfermedad vascular cerebral de tipo isquémico en jóvenes mexicanos

Content Provider	Semantic Scholar
Author	Jiménez-González, María Santiago-Germán, David Castillo-Henkel, Enrique Fernando Alvarado-Moreno, J. Antonio Hernandez-Juarez, Jesus Leaños-Miranda, Alfredo Majluf-Cruz, Abraham Isordia-Salas, Irma
Copyright Year	2018
Abstract	Resumen Introduccion Diversos polimorfismos en genes candidatos que codifican proteinas del sistema hemostatico se han propuesto como factores de riesgo para el desarrollo de trombosis. Metodos Casos y controles, sobrevivientes de enfermedad vascular cerebral (EVC) isquemica idiopatica ≤ 45 anos de edad del servicio de neurologia incluidos de manera consecutiva de 2006 a 2014. Por PCR-RFLP se identificaron los polimorfismos: Thr325Ile y Ala147Thr del gen de TAFI, 4G/5G del gen de PAI-1, PLA1/A2 del gen de la glucoproteina plaquetaria IIb/IIIa, Glu298Asp del gen de eNOS, y C677T del gen de la 5,10 MTHFR. Se realizo un analisis multivariado de regresion logistica para calcular el riesgo independiente de EVC. Resultados Doscientos cuatro casos y 204 controles pareados por edad y sexo. Se asocio al polimorfismo Glu298Asp (genotipo p = 0,001 y frecuencia alelica p = 0,001), C677T (genotipo p = 0,01), hipertension (p = 0,03) y tabaquismo (p = 0,02) con la presencia de EVC isquemico, no asi para los polimorfismos Ala147Thr, Thr325IIe, 4G/5G y PLA1/A2. Se identifico como factor de riesgo independiente al alelo 298Asp (p = 0,03), T (p = 0,01), hipertension (p = 0,03), tabaquismo (p = 0,01) y AHFEAT (p = 0,04). Conclusiones Los polimorfismos Glu298Asp y C677T de los genes que codifican a la enzima eNOS y 5,10 MTHFR, tabaquismo, hipertension y AHFEAT se asociaron a la presencia de EVC isquemico en jovenes mexicanos, no asi el Thr325Ile, Ala147Thr, 4G/5G, PLA1/A2 en genes que codifican proteinas del sistema de fibrinolisis y receptores plaquetarios.
File Format	PDF HTM / HTML
DOI	10.1016/j.nrl.2018.01.010
Alternate Webpage(s)	https://www.elsevier.es/index.php?p=revista&pRevista=pdf-simple&pii=S021348531830032X
Alternate Webpage(s)	https://doi.org/10.1016/j.nrl.2018.01.010
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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