NDLI: The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease

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The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease

Content Provider	Semantic Scholar
Author	Sutliff, Roy Lee Hart, Craig M.
Copyright Year	2007
Abstract	Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in both systemic and pulmonary vascular disease and function. Existing treatment strategies for pulmonary hypertension, the most common manifestation of pulmonary vascular disease, are limited by an incomplete understanding of the underlying disease pathogenesis and lack of efficacy indicating an urgent need for new approaches to treat this disorder. Derangements in pulmonary endothelial-derived mediators and endothelial dysfunction have been shown to play a pivotal role in pulmonary hypertension pathogenesis. Therefore, the following review will focus on selected mediators implicated in pulmonary vascular dysfunction and evidence that PPARs, in particular PPARgamma, participate in their regulation and may provide a potential novel therapeutic target for the treatment of pulmonary hypertension.
Starting Page	645
Ending Page	650
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	17710111
Volume Number	2007
Journal	PPAR research
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/69/e0/PPAR2007-18797.PMC1940049.pdf
Alternate Webpage(s)	http://downloads.hindawi.com/journals/ppar/2007/018797.pdf
Language	English
Access Restriction	Open
Subject Keyword	Chronic Obstructive Airway Disease Hormone Receptor Hypertensive disease Ligands Nuclear Hormone Receptors PPAR gamma Paget's Disease, Mammary Peroxisome Proliferator-Activated Receptors Peroxisome Proliferators Physiological Processes Pulmonary Hypertension TRANSCRIPTION FACTOR Tuberculosis, Pulmonary Vascular Diseases
Content Type	Text
Resource Type	Article

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