NDLI: Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase.

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Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase.

Content Provider	Semantic Scholar
Author	Le, Ngoc Khang Simon, Meredith A.
Copyright Year	1998
Abstract	DRK, the Drosophila homolog of the SH2-SH3 domain adaptor protein Grb2, is required during signaling by the sevenless receptor tyrosine kinase (SEV). One role of DRK is to provide a link between activated SEV and the Ras1 activator SOS. We have investigated the possibility that DRK performs other functions by identifying additional DRK-binding proteins. We show that the phosphotyrosine-binding (PTB) domain-containing protein Disabled (DAB) binds to the DRK SH3 domains. DAB is expressed in the ommatidial clusters, and loss of DAB function disrupts ommatidial development. Moreover, reduction of DAB function attenuates signaling by a constitutively activated SEV. Our biochemical analysis suggests that DAB binds SEV directly via its PTB domain, becomes tyrosine phosphorylated upon SEV activation, and then serves as an adaptor protein for SH2 domain-containing proteins. Taken together, these results indicate that DAB is a novel component of the SEV signaling pathway.
File Format	PDF HTM / HTML
DOI	10.1128/MCB.18.8.4844
PubMed reference number	9671493
Journal	Medline
Volume Number	18
Issue Number	8
Alternate Webpage(s)	http://web.stanford.edu/group/simonlab/PDF%20files/Le%20and%20Simon,%201998.pdf
Alternate Webpage(s)	https://doi.org/10.1128/MCB.18.8.4844
Journal	Molecular and cellular biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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