NDLI: Deferasirox Versus Deferoxiamine for the Treatment of Transfusional Iron Overload in Patients with β-Thalassemia Major

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Deferasirox Versus Deferoxiamine for the Treatment of Transfusional Iron Overload in Patients with β-Thalassemia Major

Content Provider	Semantic Scholar
Author	Ibrahiem, Osama Ahmed Thabet, Ahmed F.
Copyright Year	2014
Abstract	Background: Many patients with transfusional ironoverload are at risk of progressive organ dysfunctionand early death. Poor compliance with iron chelators isbelieved to be a major contributing factor. Objectives: Theaim of this study is to evaluate the efficacy of Deferasiroxin comparison with Deferoxiamine for the treatment oftransfusional iron overload in patients with β-thalassemiamajor. Patients and Methods: We evaluated the oncedailyDeferasirox for 48 weeks in forty patients (olderthan 2 years) who had β-thalassaemia major with evidenceof iron overload. Some had been previously treated withchelating agents. Most patients began treatment with Deferasirox 10 mg⁄ kg ⁄ day and may be increased to 30 mg/kg/day. Serum ferritin level was assessed before and afterbeginning of Deferasirox treatment at 3 months intervalfor 48 weeks. Results: Deferasirox was associated withmild adverse events on most occasions. The mean serumferritin level decreased significantly in all patients treatedwith Deferasirox compared to those on Deferoxiamine. Conclusions: Administration of Deferasirox as an oraldrug may be preferable and more effecatious than theparentral iron chelating therapy with better compliance andno inconvenience of parenteral infusion regimens. Key words: Deferasirox, Deferoxiamine, Transfusionaliron overload, β-thalassemia major.
Starting Page	14
Ending Page	18
Page Count	5
File Format	PDF HTM / HTML
DOI	10.4103/1947-489X.210350
Volume Number	6
Alternate Webpage(s)	http://www.aun.edu.eg/uploaded_full_txt/15897_full_txt.pdf
Alternate Webpage(s)	https://doi.org/10.4103/1947-489X.210350
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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