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Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hutvagner, Gyorgy |
| Copyright Year | 2005 |
| Abstract | RNAi is a conserved gene-specific regulatory mechanism, which silences target gene expression transcriptionally and post-transcriptionally. The RNAi machinery converts the sequence specific information of a long double stranded RNAs (dsRNAs) into small 21-22 nt long dsRNAs (siRNAs, miRNAs) which assemble into an effector complex, the RNA induced silencing complex (RISC). RISC assembly is asymmetric; one strand of an siRNA or a miRNA preferentially incorporates into the RNA-protein complex. Here, I review the rules of the asymmetric RISC formation and discuss their possible regulatory function in several steps in RNAi. |
| Starting Page | 1 |
| Ending Page | 7 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://opus.lib.uts.edu.au/bitstream/10453/15313/1/2010003457.pdf |
| PubMed reference number | 16199039v1 |
| Volume Number | 579 |
| Issue Number | 26 |
| Journal | FEBS letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Candidate Disease Gene Gene Expression Regulation MicroRNAs RNA Interference RNA, Double-Stranded RNA-Induced Silencing Complex Rule (guideline) negative regulation of nonmotile primary cilium assembly |
| Content Type | Text |
| Resource Type | Article |
