New laxative constituents of rhubarb. Isolation and characterization of rheinosides A, B, C and D.

Content Provider	Semantic Scholar
Author	Yamagishi, Takashi Nishizawa, Masahiro Ikura, Mitsuhiko Hikichi, Kunio Nonaka, Gen-Ichiro Nishioka, Itsuo
Copyright Year	1987
Abstract	Rhubarb (Rhei Rhizoma) has been used as an important traditional crude drug in China and Japan, and as a laxative medicine in European countries. Many investigators have studied the constituents of rhubarb, and it has been shown to contain anthraquinones,3) dianthrones (sennosides),4) naphthalenes,5) stilbenes,6, 7) phenylbutanones,7 -9) chromones,10) etc. Recently, we have reported the isolation and characterization of highly water-soluble polyphenolic compounds (rhatannin)8) which decreased urea nitrogen concentration in rat serum, and other tannin-related compounds.8,9,11,12) Chemical and pharmacological studies of rhubarb have revealed that sennosides A-F are active principles.4) Our systematic investigation on the water-soluble fraction of rhubarb, however, has resulted in the isolation of four new laxative C-glucosides. In this paper, we report the characterization and laxative activity of these new principles. A commercial rhubarb (Gaoh, produced in Sichuan province in China) obtained in Osaka market was extracted with 50% aqueous acetone, and the extract was partitioned between ethyl acetate and water. The water-soluble portion containing a mixture of
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/cpb1958/35/8/35_8_3132/_pdf/-char/en
PubMed reference number	3427702v1
Volume Number	35
Issue Number	8
Journal	Chemical & pharmaceutical bulletin
Language	English
Access Restriction	Open
Subject Keyword	Acetone Black Cohosh Extract Blood Urea Nitrogen Extraction Iridoid Glucosides Laxatives Pharmacology Rhizome Rhubarb food Tannic Acid ethyl acetate sennosides, USP
Content Type	Text
Resource Type	Article