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Genetic ACE I/D and ACTN3 R577X polymorphisms and adolescent idiopathic scoliosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Luciano, Rafael De Paiva Wajchenberg, Marcelo Almeida, Sebastião Sousa Amorim, Carlos E. Neves Rodrigues, L. M. R. Araújo, Roberta Faria C. Puertas, Eduardo Barros Faloppa, Flávio |
| Copyright Year | 2016 |
| Abstract | The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and α-actinin-3. Ninety-seven females with scoliosis, and 137 healthy, age-matched control females were studied. The presence of polymorphisms was determined by PCR. A χ2 test was used to analyze differences, and odds ratios were estimated. The frequencies of ACE genotypes in the scoliotic group were 46.4% DD, 45.4% ID, and 8.2% II, while in the control group they were 40.1% DD, 43.8% ID, and 16.1% II (P = 0.197). The D allele had a frequency of 69.1% in patients with idiopathic scoliosis and 62% in the control group (P = 0.116). The frequencies of ACTN3 genotypes in females with scoliosis were 31.8% RR, 49.4% RX, and 18.8% XX, while in the control group they were 35% RR, 49% RX, and 16% XX (P = 0.810). The frequency of the R allele was 56.4% in the scoliotic group and 59.6% in the control group (P = 0.518). There was no statistically significant association between angiotensin-converting enzyme or α-actinin-3 polymorphisms and the presence of adolescent idiopathic scoliosis in females. |
| File Format | PDF HTM / HTML |
| DOI | 10.4238/gmr15048959 |
| PubMed reference number | 27819725 |
| Journal | Medline |
| Volume Number | 15 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.funpecrp.com.br/gmr/year2016/vol15-4/pdf/gmr-15-gmr15048959.pdf |
| Alternate Webpage(s) | https://doi.org/10.4238/gmr15048959 |
| Journal | Genetics and molecular research : GMR |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
