NDLI: Kinetics of antiviral activity by human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL) and rapid selection of CTL escape virus in vitro.

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Kinetics of antiviral activity by human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL) and rapid selection of CTL escape virus in vitro.

Content Provider	Semantic Scholar
Author	Baalen, Carel A. Van Schutten, Martin Huisman, Rudolf Boers, Patrick H. M. Gruters, Rob A. Osterhaus, Albert D. M. E.
Copyright Year	1998
Abstract	The antiviral activity of a CD8(+) cytotoxic T-lymphocyte (CTL) clone (TCC108) directed against a newly identified HLA-B14-restricted epitope, human immunodeficiency virus type 1 (HIV-1) Rev(67-75) SAEPVPLQL, was analyzed with respect to its kinetics of target cell lysis and inhibition of HIV-1 production. Addition of TCC108 cells or CD8(+) reverse transcriptase-specific CTLs to HLA-matched CD4(+) T cells at different times after infection with HIV-1 IIIB showed that infected cells became susceptible to CTL-mediated lysis before peak virus production but after the onset of progeny virus release. When either of these CTLs were added to part of the infected cells immediately after infection, p55 expression and virus production were significantly suppressed. These data support a model in which CTLs, apart from exerting cytolytic activity which may prevent continued virus release, can interfere with viral protein expression during the eclipse phase via noncytolytic mechanisms. TCC108-mediated inhibition of virus replication in peripheral blood mononuclear cells caused rapid selection of a virus with a mutation (69E-->K) in the Rev(67-75) CTL epitope which abolished recognition by TCC108 cells. Taken together, these data suggest that both cytolytic and noncytolytic antiviral mechanisms of CTLs can be specifically targeted to HIV-1-infected cells.
File Format	PDF HTM / HTML
DOI	10.1128/jvi.72.8.6851-6857.1998
PubMed reference number	9658134
Journal	Medline
Volume Number	72
Issue Number	8
Alternate Webpage(s)	https://repub.eur.nl/pub/8857/9658134.pdf
Alternate Webpage(s)	https://doi.org/10.1128/jvi.72.8.6851-6857.1998
Journal	Journal of virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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