Successful childbirth in a patient with chronic myelogenous leukemia treated with imatinib mesylate during early pregnancy.

Content Provider	Semantic Scholar
Author	Skoumalová, Ivana Vondrakova, Jana Rohon, Peter Rozmanová, Sárka Jarosova, Marie Indrák, Karel Procházka, Martin Śantavá, Alena Faber, Edgar
Copyright Year	2008
Abstract	AIMS To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the first 4 months of pregnancy. RESULTS Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the first four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again. CONCLUSIONS We discuss possible strategies for successful management of pregnancy in CML patients treated with imatinib.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://biomed.papers.upol.cz/savepdfs/bio/2008/01/19.pdf
PubMed reference number	18795086v1
Volume Number	152
Issue Number	1
Journal	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
Language	English
Access Restriction	Open
Subject Keyword	Clone Congenital Abnormality Fetal Diseases Imatinib mesylate Mesylates Myeloid Leukemia Myeloid Leukemia, Chronic Patients Polymerase Chain Reaction Retreatments
Content Type	Text
Resource Type	Article