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Effect of Low versus High Frequency Subthalamic Deep Brain Stimulation on Speech Intelligibility and Verbal Fluency in Parkinson's Disease: A Double-Blind Study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grover, Timothy W. Georgiev, Dejan Kalliola, Rania Mahlknecht, Philipp Zacharia, André Candelario, Joseph Hyam, Jonathan Zrinzo, Ludvic U. Hariz, Marwan I. Foltynie, Thomas Limousin, Patricia Jahanshahi, Marjan Tripoliti, Elina |
| Copyright Year | 2019 |
| Abstract | BACKGROUND Subthalamic deep brain stimulation (STN-DBS) is an established treatment for late stage Parkinson's disease (PD). Speech intelligibility (SI) and verbal fluency (VF) have been shown to deteriorate following chronic STN-DBS. It has been suggested that speech might respond favourably to low frequency stimulation (LFS). OBJECTIVE We examined how SI, perceptual speech characteristics, phonemic and semantic VF and processes underlying it (clustering and switching) respond to LFS of 60 and 80 Hz in comparison to high frequency stimulation (HFS) (110, 130 and 200 Hz). METHODS In this double-blind study, 15 STN-DBS PD patients (mean age 65, SD = 5.8, 14 right handed, three females), were assessed at five stimulation frequencies: 60 Hz, 80 Hz, 110 Hz, 130 Hz and 200 Hz. In addition to the clinical neurological assessment of speech, VF and SI were assessed. RESULTS SI and in particular articulation, respiration, phonation and prosody improved with LFS (all p < 0.05). Phonemic VF switching improved with LFS (p = 0.005) but this did not translate to an improved phonemic VF score. A trend for improved semantic VF was found. A negative correlation was found between perceptual characteristics of speech and duration of chronic stimulation (all p < 0.05). CONCLUSIONS These findings highlight the need for meticulous programming of frequency to maximise SI in chronic STN-DBS. The findings further implicate stimulation frequency in changes to specific processes underlying VF, namely phonemic switching and demonstrate the potential to address such deficits through advanced adjustment of stimulation parameters. |
| Starting Page | 141 |
| Ending Page | 151 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.3233/JPD-181368 |
| PubMed reference number | 30594934 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://discovery.ucl.ac.uk/10067419/3/Grover_Low%20frequency%20effects%20on%20speech%20characteristics_final_after_2nd_revision_final.pdf |
| Alternate Webpage(s) | https://doi.org/10.3233/JPD-181368 |
| Journal | Journal of Parkinson's disease |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
