NDLI: Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumors.

Content Provider	Semantic Scholar
Author	Li, Jindan Hai, Zijuan Xiao, Huiqiong Yi, Xiao-Yi Liang, Gaolin
Copyright Year	2018
Abstract	Nanoprobes are advantageous over small molecular probes in sensitivity but most luminescence molecules used to construct nanoprobes often suffer from an aggregation-caused quenching effect. Herein, we rationally designed a small molecular probe Cys(StBu)-Lys(Ru(bpy)32+)-CBT (1) which "smartly" self-assembled into nanoparticles 1-NPs inside cells with non-quenched, persistent phosphorescence. Employing this property, we successfully applied 1 for long-term sensing of biothiol activity in living HepG2 cells and tumors. We envision that, by modifying the amino group with an enzyme substrate, our probe 1 could be further developed for sensing intracellular enzyme activity with non-quenched, persistent phosphorescence.
Starting Page	3460
Ending Page	3463
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1039/C8CC01759J
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/cc/c8cc01759j/c8cc01759j1.pdf
PubMed reference number	29560995
Alternate Webpage(s)	https://doi.org/10.1039/C8CC01759J
Volume Number	54
Issue Number	28
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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