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WOMEN IN CANCER THEMATIC REVIEW: Thyroid-stimulating hormone in thyroid cancer: does it matter?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Boelaert, Kristien |
| Copyright Year | 2016 |
| Abstract | Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surgery is often required for patients suspected to have malignancy. Serum thyroid-stimulating hormone (TSH) is higher in patients with malignant thyroid nodules than in those with benign disease, and TSH is proportionally increased in more aggressive tumours. Importantly, we have shown that the pre-operative serum TSH concentration independently predicts the presence of malignancy in subjects presenting with thyroid nodules. Establishing the use of TSH measurements in algorithms identifying high-risk thyroid nodules in routine clinical practice represents an exciting, cost-efficient and non-invasive approach to optimise thyroid cancer diagnosis. Binding of TSH to receptors on thyrocytes stimulates a number of growth promoting pathways both in normal and malignant thyroid cells, and TSH suppression with high doses of levothyroxine is routinely used after thyroidectomy to prevent cancer recurrence, especially in high-risk tumours. This review examines the relationship between serum TSH and thyroid cancer and reflects on the clinical potential of TSH measurements in diagnosis and disease monitoring. |
| Starting Page | T109 |
| Ending Page | T121 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://erc.endocrinology-journals.org/content/23/11/T109.full.pdf |
| Alternate Webpage(s) | https://erc.bioscientifica.com/downloadpdf/journals/erc/23/11/T109.pdf |
| PubMed reference number | 27633516v1 |
| Volume Number | 23 |
| Issue Number | 11 |
| Journal | Endocrine-related cancer |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anaplastic thyroid carcinoma Anatomic Node Differentiated Thyroid Gland Carcinoma Endocrine System Diseases Fine needle aspiration biopsy Lymphadenopathy Malignant Childhood Central Nervous System Neoplasm Meta Analysis (statistical procedure) Neoplasms Papillary thyroid carcinoma Patients Progressive Disease Promotion (action) Stimulation (motivation) Stratification Surgical revision Thyroid Diseases Thyroid Gland Follicular Cell Thyroid Neoplasm Thyroid Nodule Thyroidectomy Thyrotropin Tumor Progression algorithm levothyroxine lymph nodes |
| Content Type | Text |
| Resource Type | Article |
