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Application of immunohistochemistry to breast lesions.

Content Provider	Semantic Scholar
Author	Yeh, I. Mies, Carolyn
Copyright Year	2008
Abstract	CONTEXT Immunohistochemistry has an expanding role in mammary pathology that has been facilitated by a growing list of available antibodies and a better understanding of biology. OBJECTIVE To explore the key role of immunohistochemistry in guiding adjuvant therapy decisions and sentinel node staging in breast cancer, as well as the role of immunohistochemistry as an aid to distinguishing usual ductal hyperplasia from atypical ductal hyperplasia/low-grade carcinoma in situ; subtyping a carcinoma as ductal or lobular, basal or luminal; ruling out microinvasion in extensive intraductal carcinoma; distinguishing invasive carcinoma from mimics; and establishing that a metastatic carcinoma of unknown primary site has originated in the breast. DATA SOURCES Current literature is reviewed, including clinical and pathologic journals. CONCLUSIONS As new, targeted treatments for breast cancer are developed, pathologists can expect additional immunohistochemistry applications in the future.
Starting Page	545
Ending Page	552
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.comanes.org/cursotaller/IHQtoBreastLesions.pdf
PubMed reference number	18318578v1
Alternate Webpage(s)	https://doi.org/10.1043/1543-2165(2008)132[349:AOITBL]2.0.CO;2
DOI	10.1043/1543-2165(2008)132[349:AOITBL]2.0.CO;2
Journal	Archives of pathology & laboratory medicine
Volume Number	132
Issue Number	3
Language	English
Access Restriction	Open
Subject Keyword	Atypical Ductal Breast Hyperplasia Carcinoma in Situ Intraductal Hyperplasia Invasive Carcinoma Mammary Neoplasms Metastatic Carcinoma Noninfiltrating Intraductal Carcinoma Pharmaceutical Adjuvants Phenobarbital Sentinel Lymph Node
Content Type	Text
Resource Type	Article

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