NDLI: Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging

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Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging

Content Provider	Semantic Scholar
Author	Mei, Xiao Ning Chen, Dongyun Li, Najun Xu, Qingfeng Ge, Jian-Feng Yang, Bai-Xia Xu, Yu-Jie Lu, Jianmei
Copyright Year	2012
Abstract	A smart fluorescent drug carrier based on hollow mesoporous silica (HMS) nanoparticles was prepared step by step. First, HMS nanoparticles were doped with lanthanide rare-earth nanocrystals (YVO4:Eu3+). Then the surface of HMS@YVO4:Eu3+ was modified by octadecyltrimethoxysilane (C18). Afterwards, it was coated by designed pH-sensitive amphiphilic diblock copolymer (poly(MPEG-b-DBAM), PMD) through hydrophobic van der Waals interactions. The results of characterization such as transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR) reveal that the material shows excellent monodisperse spherical morphology and narrow size distribution (180 nm) with hollow-core@mesoporous-silica-shell@thin-polymer-film structure. The multifunctional system HMS@YVO4:Eu3+@C18@PMD was utilized to deliver the model drug ibuprofen (IBU), and the drug loading content of the system is as high as 834 mg/g (drug/carrier). Due to the coated pH-sensitive polymer film, the loaded drug is selectively released in mildly acidic environment. The time of release of about 80% drug was however prolonged from 50 to 150 h (at pH = 5.0) by the effect of modified C18, which has thus achieved longer-term release. Besides, the prepared material is easily imported into human mouth epidermal carcinoma (KB) cells and showed good and stable red fluorescence, which is suitable for cell imaging.
Starting Page	5309
Ending Page	5316
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C2SM07320J
Alternate Webpage(s)	http://www.rsc.org/suppdata/sm/c2/c2sm07320j/c2sm07320j.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C2SM07320J
Volume Number	8
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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