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Unloading‐induced atrophy and decreased oxidative capacity of the soleus muscle in rats are reversed by pre‐ and postconditioning with mild hyperbaric oxygen
| Content Provider | Semantic Scholar |
|---|---|
| Author | Takemura, Ai Roy, Roland R. Yoshihara, Ikumi Ishihara, Akihiko |
| Copyright Year | 2017 |
| Abstract | Our aim was to determine the effects of pre- and/or postconditioning with mild hyperbaric oxygen (1.25 atmospheric pressure, 36% oxygen for 3 h/day) on the properties of the soleus muscle that was atrophied by hindlimb suspension-induced unloading. Twelve groups of 8-week-old rats were housed under normobaric conditions (1 atmospheric pressure, 20.9% oxygen) or exposed to mild hyperbaric oxygen for 2 weeks. Ten groups then were housed under normobaric conditions for 2 weeks with their hindlimbs either unloaded via suspension or not unloaded. Six groups subsequently were either housed under normobaric conditions or exposed to mild hyperbaric oxygen for 2 weeks: the suspended groups were allowed to recover under reloaded conditions (unrestricted normal cage activity). Muscle weights, cross-sectional areas of all fiber types, oxidative capacity (muscle succinate dehydrogenase activity and fiber succinate dehydrogenase staining intensity) decreased, and a shift of fibers from type I to type IIA and type IIC was observed after hindlimb unloading. In addition, mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α decreased, whereas those of forkhead box-containing protein O1 increased after hindlimb unloading. Muscle atrophy and decreased oxidative capacity were unaffected by either pre- or postconditioning with mild hyperbaric oxygen. In contrast, these changes were followed by a return to nearly normal levels after 2 weeks of reloading when pre- and postconditioning were combined. Therefore, a combination of pre- and postconditioning with mild hyperbaric oxygen can be effective against the atrophy and decreased oxidative capacity of skeletal muscles associated with hindlimb unloading. |
| Starting Page | 312 |
| Ending Page | 317 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://physreports.physiology.org/content/physreports/5/14/e13353.full.pdf |
| PubMed reference number | 28743823 |
| Alternate Webpage(s) | https://doi.org/10.14814/phy2.13353 |
| DOI | 10.14814/phy2.13353 |
| Journal | Physiological reports |
| Volume Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Atrophic Hindlimb Hindlimb Suspension Hyperbaric Oxygen (substance) Lower Extremity Peroxisome Proliferators Pressure Ulcer Skeletal Unloading Skeletal muscle structure Soleus muscle structure Spinocerebellar Ataxia Type 2 Staining Intensity Staining method Succinate Dehydrogenase Succinates Suspension substance Suspensions Tissue fiber Tritium Weight |
| Content Type | Text |
| Resource Type | Article |
