NDLI: Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells.

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Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells.

Content Provider	Semantic Scholar
Author	Ju, Donghong Xie, Youming
Copyright Year	2014
Abstract	The proteasome has become an important target for cancer therapy with the approval of bortezomib for the treatment of relapsed/refractory multiple myeloma (MM). However, numerous patients with MM do not respond to bortezomib and those responding initially often acquire resistance. Recent clinical studies have also demonstrated that bortezomib is also inefficacious in the treatment of other types of cancer. Therefore, it is imperative to develop novel approaches and agents for proteasome-targeting cancer therapy. In the present study, it was revealed that dyclonine, a major component of the cough droplets Sucrets, markedly enhances the cytotoxic effects of bortezomib and minimizes drug resistance in MM cells. It was demonstrated that a combination of bortezomib and dyclonine markedly induced apoptosis of MM cells. The present study suggests a novel therapeutic use of an over‑the‑counter medicine for the treatment of MM.
File Format	PDF HTM / HTML
DOI	10.3892/mmr.2014.2522
PubMed reference number	25174315
Journal	Medline
Volume Number	10
Issue Number	5
Alternate Webpage(s)	https://www.spandidos-publications.com/mmr/10/5/2609/download
Alternate Webpage(s)	https://doi.org/10.3892/mmr.2014.2522
Journal	Molecular medicine reports
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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