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Myocardial perfusion at rest in uncomplicated type 2 diabetes patients without coronary artery disease evaluated by 320-multidetector computed tomography
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cai, Xiangyi Zhang, Shuihua Deng, Dabiao Li, Honglin Guan, Xueqing Fang, Jin Xiang Zhou, Quan Spring |
| Copyright Year | 2018 |
| Abstract | Using computed tomography myocardial perfusion imaging (CTP) to investigate resting myocardial perfusion alterations in uncomplicated type 2 diabetes mellitus (T2DM) patients without obstructive coronary artery disease (CAD).A total of 34 participants with 544 myocardial segments were included prospectively: 17 uncomplicated T2DM patients with no significant coronary artery stenosis on coronary computed tomography angiography and 17 healthy controls. Myocardial perfusion was evaluated by transmural perfusion ratio (TPR). Parameters of cardiac structure and function were measured for cardiac comprehensive assessment. Analyses included descriptive statistics and group comparisons.TPR of segments 5, 7, 9, 10 to 14 were significantly reduced in T2DM group compared with controls (P < .05). When 16 myocardial segments were localized into different areas according to the wall orientations, axial levels of left ventricle and coronary artery territories, respectively, TPR of each area in T2DM group were significantly lower than those in the control group (P < .05). No significant differences were found in cardiac anatomy and function analyses between 2 groups.In uncomplicated T2DM patients without obstructive CAD, myocardial perfusion impairments were present and may develop prior to cardiac morphological and functional abnormalities, which can be early detected by CTP. |
| Starting Page | 325 |
| Ending Page | 335 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29384863v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000009762 |
| DOI | 10.1097/MD.0000000000009762 |
| Journal | Medicine |
| Volume Number | 97 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic structures Arterial stenosis Arteriopathic disease Cardiomyopathies Computed Tomography Angiography Congenital Abnormality Coronary Artery Disease Coronary Stenosis Description Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Diabetic Heart Disease Heart Diseases Heart Ventricle Left ventricular structure Mental Orientation Myocardial Infarction Myocardial Ischemia Myocardial Perfusion Imaging Myocardium Patients Rest X-Ray Computed Tomography angiogram |
| Content Type | Text |
| Resource Type | Article |
