NDLI: Osthole attenuates myocardial ischemia/reperfusion injury in rats by inhibiting apoptosis and inflammation.

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Osthole attenuates myocardial ischemia/reperfusion injury in rats by inhibiting apoptosis and inflammation.

Content Provider	Semantic Scholar
Author	Wu, Jingguo Yang, Yang Zeng, Lijin Li, Zuolin Yang, Wen Liang, Yanbing Ma, Zhongfu Tang, Hao
Copyright Year	2018
Abstract	This study was performed to evaluate the cardioprotective effects of osthole (OST) in a rat model of myocardial ischemia/reperfusion injury (MI/RI) and the underlying mechanism. We exposed rat hearts to left anterior descending coronary artery ligation for 30 min followed by 24 h of reperfusion. The results showed that pretreatment with OST ameliorated MI/RI as evidenced by histopathological examination. Moreover, the terminal deoxynucleotidyl transferase dUTP nick end-labeling assay demonstrated that OST suppressed myocardial apoptosis, which may be related to an increase in the Bcl-2/Bax ratio and inhibition of caspase-3 and caspase-9 activation. Furthermore, we determined that OST ameliorated impaired mitochondrial morphology and the oxidation system; OST also attenuated levels of pro-inflammatory cytokines, including tumor necrosis factor α and interleukins 6 and 1β. In conclusion, OST exerted a strong favorable cardioprotective effect on MI/RI, possibly by suppressing the inﬂammatory response and inhibiting cell apoptosis.
Starting Page	1109
Ending Page	1116
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	29736204
Journal	Medline
Volume Number	10
Issue Number	4
Alternate Webpage(s)	http://www.ajtr.org/files/ajtr0074762.pdf
Journal	American journal of translational research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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