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Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Nai-Si Chi, Ya-yun Xue, Jing-yan Liu, Meng-ying Huang, Sheng Mo, Miao Zhou, Shu-ling Wu, Jiong |
| Copyright Year | 2016 |
| Abstract | Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1), a lncRNA that was first recognized as a prognostic parameter for patient survival of stage I lung cancer, is up-regulated in multiple human malignancies, including breast cancer. However, the mechanism of its function remained elusive. In the current study, by examining MALAT1 expression on mRNA level, we demonstrated that compared with MCF10A, MALAT1 expression was up-regulated in the majority of breast cancer cell lines (9/12). In 26 pairs of estrogen receptor (ER)-positive breast cancer samples, MALAT1 expression was significantly up-regulated compared with adjacent normal tissues (P = 0.012). Furthermore, of 204 breast cancer patients, high MALAT1 expression was associated with positive ER (P = 0.023) and progesterone receptor (PR) (P = 0.024) status. Further analysis using TCGA database revealed that ER and its target genes PGR and CCND1, were overexpressed in MALAT1 altered group compared with unaltered group, both on the mRNA and protein level. Lastly, we verified MALAT1's prognostic value in breast cancer. At the cut-off value of 75%, MALAT1 was the only independent prognostic factor of recurrence-free survival (RFS) in ER-negative patients in a multivariate Cox regression model (hazard ratio [HR] = 2.83, 95% confidence interval [CI] 1.02-7.83). MALAT1 overexpression was also associated with poor RFS in tamoxifen treated ER-positive breast cancer patients, which might serve as a potential biomarker to predict endocrine treatment sensitivity. |
| Starting Page | 37957 |
| Ending Page | 37965 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27191888v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.9364 |
| DOI | 10.18632/oncotarget.9364 |
| Journal | Oncotarget |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenocarcinoma of lung (disorder) Adult Fanconi syndrome Biological Markers Body tissue CCND1 gene Carcinoma of lung Confidence Intervals Cultured Cell Line Estrogen Receptors Estrogens Hazard Ratio Leukemia, B-Cell MALAT1 gene Mammary Neoplasms Metastatic Neoplasm PGR gene Patients Population Parameter Prognostic Factors Receptors, Progesterone Stage I Lung Cancer Tamoxifen The Cancer Genome Atlas Transcript cancer cell estrogen receptor alpha, human non-T, non-B childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
