NDLI: Testosterone and cardiovascular disease : controversy or wake-up call ?

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Testosterone and cardiovascular disease : controversy or wake-up call ?

Content Provider	Semantic Scholar
Author	Yuen, Kevin C. J.
Copyright Year	2014
Abstract	In men with hypogonadism due to diseases of the hypothalamus, pituitary, or testis, testosterone therapy is generally safe and has been shown to induce beneficial effects. Conversely, in men with age-related low testosterone levels, the significance of this change and the effects of testosterone therapy are debatable. Studies have linked low testosterone levels with increased cardiovascular morbidity and mortality, with testosterone therapy being reported to improve cardiovascular risk profiles. However, two recent retrospective studies have fueled the controversy on testosterone therapy by reporting increased cardiovascular events. Because placebo-controlled, randomized clinical trials on testosterone therapy in older men with age-related decline in testosterone levels are lacking, long-term cardiovascular health following testosterone therapy in this patient population remains unclear. Therefore, a careful approach should be adopted when considering therapy of hypogonadism and coexisting cardiovascular disease in older men. Adequately powered, long-term prospective randomized trials on testosterone in older men are urgently needed. Cardiovasc Endocrinol 00:000–000 © 2014 Wolters Kluwer Health \| Lippincott Williams & Wilkins.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://universalmensclinic.com/wp-content/uploads/2014/10/TRT-CVD-review-paper-Sept-2014.pdf
Language	English
Access Restriction	Open
Subject Keyword	Cardiovascular Diseases Entity Name Part Qualifier - adopted Hypogonadism Hypothalamic structure Morbidity - disease rate Patients Power (Psychology) Prospective search Randomized algorithm Testosterone
Content Type	Text
Resource Type	Article

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