Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine).

Content Provider	Semantic Scholar
Author	Busto, Jon V. Sot, Jesús Goñi, Félix M. Mollinedo, Faustino Alonso, Alicia
Copyright Year	2007
Abstract	The surface activity and interaction with lipid monolayers and bilayers of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine) have been studied. Edelfosine is a surface-active soluble amphiphile, with critical micellar concentrations at 3.5 microM and 19 microM in water. When the air-water interface is occupied by a phospholipid, edelfosine becomes inserted in the phospholipid monolayer, increasing surface pressure. This increase is dose-dependent, and reaches a plateau at ca. 2 microM edelfosine bulk concentration. The ether lipid can become inserted in phospholipid monolayers with initial surface pressures of up to 33 mN/m, which ensures its capacity to become inserted into cell membranes. Upon interaction with phospholipid vesicles, edelfosine exhibits a weak detergent activity, causing release of vesicle contents to a low extent (<5%), and a small proportion of lipid solubilization. The weak detergent properties of edelfosine can be related to its very low critical micellar concentrations. Its high affinity for lipid monolayers combined with low lytic properties support the use of edelfosine as a clinical drug. The surface-active properties of edelfosine are similar to those of other "single-chain" lipids, e.g. lysophosphatidylcholine, palmitoylcarnitine, or N-acetylsphingosine.
File Format	PDF HTM / HTML
DOI	10.1016/j.bbamem.2007.04.025
PubMed reference number	17543274
Journal	Medline
Volume Number	1768
Issue Number	7
Alternate Webpage(s)	https://core.ac.uk/download/pdf/81130356.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.bbamem.2007.04.025
Journal	Biochimica et biophysica acta
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article